His luck was broken, he was unlucky
His luck became worse. He was not fortunate. An unlucky event happened to him (in Aramaic, 'איתרע' means 'became worse').
("You took and placed it on the horn's back, it burned and her luck was broken" - Chagigah 5a; and: "But in this matter, if one's luck is broken, and he came incidentally to your city and was caught, and must stand trial there, would you say his companion must also be tried there? This is very unlikely" - Responsa Rema, Siman 75; and: "He evokes compassion in the hearts of all who see him, like a lost sheep, whose luck was broken and wandered in the desert" - Mendele/Small Stories, Beseter Raam)
Translation
Expression (Hebrew)
אִתְּרַע מַזָּלוֹ, אִתְּרַע לוֹ מַזָּלוֹ
Definition (Hebrew)
הוּרַע מַזָּלוֹ. לֹא נִתְמַזֵּל מַזָּלוֹ. קָרָה לוֹ אֵרוּעַ חֲסַר מַזָּל (אִתְּרַע בַּאֲרָמִית מַשְׁמָע הוּרַע).
("שקלתא ואנחתא אגבה דכרעה, קדחא ואיתרע מזלה"-חֲגִיגָה ה ע"א, וְכֵן:"אֲבָל בנדון זֶה שֶׁאִם אתרע מַזָּלוֹ שֶׁל אֶחָד מֵהֶם, שֶׁבָּא דֶּרֶךְ עראי לעירך ונתפס, שֶׁצָּרִיךְ לַעֲמֹד שֵׁם לדין, תֹּאמַר שֶׁגַּם חבירו יִצְטָרֵךְ לדון שֵׁם, רָחוֹק הַדָּבָר מְאֹד"- שׁוּ"ת הרמ"א סִימָן עה, וְכֵן:"מֵעוֹרֵר עָלָיו רַחֲמִים בְּלֵב כָּל רואיו כְּשֶׂה אובד ,שאיתרע מַזָּלוֹ ונתעה בְּמִדְבַּר"-מֶנְדֵּלֵי / סִפּוּרִים קְטַנִּים, בְּסֵתֶר רַעַם)