His hand was heavy on/ to treat severely (harshly)/ come down heavily upon/ to oppress

The hardship on another person's life. The imposition of restrictions.

("And the hand of the Lord was great against the Ashdodites, and he destroyed them, and he struck them with a great multitude, even Ashdod and its borders" - 1 Samuel 5:6 (after the fall of the Ark of the Lord into the hands of the Philistines), and also: "The Ishmaelites in Jerusalem began to grumble in their tents and to be angry in their seats at the authority, which was heavy on them and taking taxes from them" - Y. Borla/ Kissufim, 158)

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